CELL-ADHESION IN THE STROMAL REGULATION OF HEMATOPOIESIS

被引：78

作者：

CLARK, BR

GALLAGHER, JT

DEXTER, TM

机构：

[1] PATERSON INST CANC RES, CANC RES CAMPAIGN, DEPT EXPTL HAEMATOL, MANCHESTER M20 9BX, ENGLAND

[2] UNIV MANCHESTER, CANC RES CAMPAIGN, DEPT MED ONCOL, MANCHESTER M13 9PL, LANCS, ENGLAND

来源：

BAILLIERES CLINICAL HAEMATOLOGY | 1992年 / 5卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/S0950-3536(11)80010-7

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Haemopoiesis occurs in close physical contact with elements of the bone marrow stroma. This review examines some adhesion molecules which are expressed in haemopoietic environments. These molecules may act to main- tain cell contact between haemopoietic progenitors and the cellular and extracellular matrix elements of the marrow stroma. A review is undertaken of several families of adhesion molecules and their ligands, including inte- grins, CD44, LEC-CAMs, CAMs and variant glycosylation patterns expressed by haemopoietic cells. Both CD44 and integrin receptors have been implicated in mediating important cellular interactions within the haemopoietic system and the significance of these and other molecules in haemopoiesis is discussed. © 1992, Baillière Tindall. All rights reserved.

引用

页码：619 / 652

页数：34

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