IMPROVED METHOD FOR THE PREPARATION OF GUANIDINES

被引：250

作者：

KIM, KS

QIAN, LG

机构：

[1] The Bristol-Myeis Squibb Pharmaceutical Research Institute, NJ 08543-4000

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 48期

关键词：

D O I：

10.1016/S0040-4039(00)61537-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Use of N,N'-di-(tert-butoxycarbonyl)thiourea 1 in the presence of mercuric chloride provides a very efficient method for the bis-Boc protected guanidine formation of the amino compounds which are highly deactivated either sterically or electronically.

引用

页码：7677 / 7680

页数：4

共 5 条

[1] 1H-PYRAZOLE-1-CARBOXAMIDINE HYDROCHLORIDE - AN ATTRACTIVE REAGENT FOR GUANYLATION OF AMINES AND ITS APPLICATION TO PEPTIDE-SYNTHESIS
BERNATOWICZ, MS
WU, YL
MATSUEDA, GR
[J]. JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (08) : 2497 - 2502
[2] PREPARATION OF N,N'-BIS-TERT-BUTOXYCARBONYLTHIOUREA
IWANOWICZ, EJ
POSS, MA
LIN, J
[J]. SYNTHETIC COMMUNICATIONS, 1993, 23 (10) : 1443 - 1445
[3] MILLER AE, 1986, SYNTHESIS-STUTTGART, P777
[4] A MILD AND EFFICIENT METHOD FOR THE PREPARATION OF GUANIDINES
POSS, MA
IWANOWICZ, E
REID, JA
LIN, J
GU, ZX
[J]. TETRAHEDRON LETTERS, 1992, 33 (40) : 5933 - 5936
[5] YAMAMOTO Y, 1991, CHEM AMIDINES IMIDAT, V2, pCH10

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