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A SIGNALING PATHWAY GOVERNING EARLY THYMOCYTE MATURATION

被引：69
作者：
ANDERSON, SJ
PERLMUTTER, RM
机构：
[1] UNIV WASHINGTON, DEPT IMMUNOL, SEATTLE, WA 98195 USA
[2] UNIV WASHINGTON, DEPT BIOCHEM, SEATTLE, WA 98195 USA
[3] UNIV WASHINGTON, DEPT MED, DIV MED GENET, SEATTLE, WA 98195 USA
来源：
IMMUNOLOGY TODAY | 1995年 / 16卷 / 02期
关键词：
D O I：
10.1016/0167-5699(95)80096-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent evidence supports the view that p56(lck), a non-receptor protein tyrosine Kinase, serves as the signaling element that 'senses' synthesis of a functional T-cell receptor beta chain, thereby promoting thymocyte maturation. Here, Steven Anderson and Roger Perlmutter review current data, and outline the features of this developmental program.
引用
收藏
页码：99 / 105
页数：7
相关论文
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  • [1] THYMIC TUMORIGENESIS INDUCED BY OVEREXPRESSION OF P56LCK
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