THE REGULATION OF NERVE GROWTH-FACTOR SYNTHESIS AND DELIVERY TO PERIPHERAL NEURONS

被引:27
作者
RUSH, RA [1 ]
MAYO, R [1 ]
ZETTLER, C [1 ]
机构
[1] CTR NEUROSCI, ADELAIDE, SA 5001, AUSTRALIA
基金
英国医学研究理事会;
关键词
NEUROTROPHIN; SECRETION; NEURONAL CONTROL; FEEDBACK REGULATION; PHYSIOLOGY; DISEASE;
D O I
10.1016/0163-7258(94)00059-C
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Recent experiments have provided new insights into the way in which the synthesis of nerve growth factor (NGF) is regulated. In particular, a variety of agents have been found to influence the cellular concentration of mRNA(NGF) and NGF both in vitro and in vivo. However, no clear mechanism has been found to indicate the existence of a feedback regulation of NGF synthesis by effector tissue innervation. We have argued in this review that some form of feedback control is likely to exist between the innervation and the cells producing the factor. One such possibility, the regulation of the availability of NGF by control of its secretion, is discussed.
引用
收藏
页码:93 / 123
页数:31
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