DSC SCREENING FOR DRUG-EXCIPIENT AND EXCIPIENT-EXCIPIENT INTERACTIONS IN POLYPHARMACEUTICALS INTENDED FOR THE ALLEVIATION OF THE SYMPTOMS OF COLDS AND FLU .3.

被引：17

作者：

BOTHA, SA

LOTTER, AP

DUPREEZ, JL

机构：

[1] POTCHEFSTROOM UNIV CHRISTIAN HIGHER EDUC, DEPT PHARMACEUT CHEM, POTCHEFSTROOM 2520, SOUTH AFRICA

[2] POTCHEFSTROOM UNIV CHRISTIAN HIGHER EDUC, IND PHARM RES INST, POTCHEFSTROOM 2520, SOUTH AFRICA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1987年 / 13卷 / 07期

关键词：

D O I：

10.3109/03639048709116229

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

DSC screening for drug-excipient interactions of a polypharmaceutical capsule dosage form containing salicylamide, ascorbic acid, pyrilamine maleate, phenylephrine hydrochloride, lactose, colloidal silicon dioxide and sodium starchglycolate was performed. The results show the following: Ascorbic acid is incompatible with lactose and sodium starch glycolate. Salicylamide is incompatible with lactose. Pyrilamide maleate is incompatible with sodium starch gylcolate. Phenylephrine hydrochloride is incompatible with lactose. Lactose is incompatible with ascorbic acid, salicylamide, pyrilamine maleate and phenylephrine hydrochloride. Sodium starch glycolate is incompatible with ascorbic acid and pyrilamine maleate. No attempt was made to determine the nature of the interactions.

引用

页码：1197 / 1215

页数：19

共 13 条

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