A NEW SYNTHESIS OF BOTH THE ENANTIOMERS OF 4-AMINO-3-HYDROXYBUTANOIC ACID (GABOB) AND MM2 CALCULATIONS FOR ROTAMERS OF THE INTERMEDIATE OXAZOLIDIN-2-ONES

被引：61

作者：

BONGINI, A ^{[1
]}

CARDILLO, G ^{[1
]}

ORENA, M ^{[1
]}

PORZI, G ^{[1
]}

SANDRI, S ^{[1
]}

机构：

[1] CNR, DIPARTIMENTO CHIM G CIAMICIAN, CTR STUDIO FIS MACROMOLEC, I-40126 BOLOGNA, ITALY

来源：

TETRAHEDRON | 1987年 / 43卷 / 19期

关键词：

D O I：

10.1016/S0040-4020(01)90313-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The easy chromatographic separation of the diastereomeric mixture of oxazolidin-2-ones 4a and 4b allows to synthesize pure R-(-)-1a and (S)-(+)-GABOB 1b. The 1H NMR pattern of 4a and 4b can be correlated with the configuration at C-5 and this relationship is confirmed by MM2 calculations for rotamers of 5-substituted oxazolidin-2-ones.

引用

页码：4377 / 4383

页数：7

共 22 条

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