EFFECTS OF SOME SUBSTANCES ON ERGOT ALKALOID PRODUCTION

被引：5

作者：

OGUNLANA, EO

RAMSTAD, E

TYLER, VE

机构：

[1] Purdue University, School of Pharmacy and Pharmacal Sciences, Lafayette, Indiana

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 01期

关键词：

Ergot alkaloids—biosynthesis; Metal ion effect—ergot alkaloid biosynthesis; Oxygenases—ergot alkaloid biosynthesis;

D O I：

10.1002/jps.2600580138

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Literature reports do not agree with regard to the influence of aeration on the ergot alkaloid production, but in general, the results bring out the need of adequate aeration for substantial alkaloid production. The beneficial influence of aeration and the absolute requirement of molecular oxygen in the biosynthesis of the alkaloids pointed to the possibility that oxygenases may be participating in their biosynthesis. Certain substances which are known to affect oxygenases have been tested for their influence on the ergot alkaloid production in shake cultures of Claviceps, strain SD/58. The effects on alkaloid production range widely: sodium L‐thyroxine produces inhibition; phenobarbital, hydrocortisone, and 3,4‐benzpyrene cause marked increases. The results lend support to the concept that one or more oxygenases are involved in the biosynthesis of the ergot alkaloids. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：143 / +

页数：1

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