ANTIGENIC DISTINCTION BETWEEN HUMAN-C9 AND GUINEA-PIG-C9

被引：3

作者：

BOYLE, MDP

OHANIAN, SH

BORSOS, T

机构：

[1] Laboratory of Immunobiology, National Cancer Institute, National Institutes of Health, Bethesda

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1979年 / 13卷 / 01期

关键词：

D O I：

10.1016/0090-1229(79)90025-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunization of rabbits with the functionally purified ninth component (C9) of human (Hu) or guinea pig (GP) complement resulted in the production of antibodies which specifically inhibited the functional activity of fluid-phase but not bound HuC9 and GPC9, respectively. There was no detectable immunochemical cross-reactivity between the two C9 species as measured by immunodiffusion, immunoelectrophoresis, and cross-neutralization. Despite these differences, HuC9 and GPC9 were found to be interchangeable for the hemolysis of antibody-sensitized sheep erythrocyte EAC1-8hu or EAC1-7hu8gp cells. Immunization of the rabbits with either species of C9 resulted in a 5- to 10-fold depletion of the number of hemolytically effective C9 molecules in their serum. © 1979.

引用

页码：103 / 112

页数：10

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