IDIOTYPE IN MYELOMA TERMINATING IN ERYTHROLEUKEMIA

被引：4

作者：

BARCOS, M

KIM, S

SEON, BK

NUSSBAUM, A

GAILANI, S

HENDERSON, ES

机构：

[1] Departments of Pathology, Roswell Park Memorial Institute, Unit of the New York, State Department of Health, Buffalo

[2] Departments of Immunology Research, Roswell Park Memorial Institute (a unit of the New York State Department of Health, Buffalo

[3] Departments of Medical Oncology, Roswell Park Memorial Institute, (a unit of the New York State Department of Health, Buffalo

[4] Department of Pathology, Brooke Army Medical Center, San Antonio, Texas, 78234, Fort Sam Houston

[5] St. Catharines Hospital, East Chicago, Indiana, 46312

来源：

MEDICAL AND PEDIATRIC ONCOLOGY | 1979年 / 7卷 / 04期

关键词：

chromosome defects; erythroleukemia; idiotype; myeloma;

D O I：

10.1002/mpo.2950070409

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A patient with multiple myeloma, IgGK type, developed erythroleukemia with cytogenetic abnormalities three years after diagnosis. The latter disease progressed terminally to acute granulocytic leukemia. Anti‐idiotype antibody reagents were prepared by injecting rabbits with the purified monoclonal IgGK obtained from the patient's serum and subsequent absorption of the antisera with normal IgG coupled to Sepharose 4B. These reagents reacted specifically with autologous myeloma cells but failed to react with all tested allogeneic cells: these included myeloma cells, reactive lymphocytes and plasma cells, and established lymphoid cell lines. Common idiotypic determinants were found in lymphoid and plasmacytic cells of the patient's marrow, spleen, lymph node, and gastrointestinal tract at autopsy that were not present in the leukemic population. The findings indicate that myeloma and granulocytic leukemia cells have separate clonal origins. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：341 / 349

页数：9

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