THE PLASMA DISTRIBUTION OF BENZOPORPHYRIN DERIVATIVE AND THE EFFECTS OF PLASMA-LIPOPROTEINS ON ITS BIODISTRIBUTION

被引：80

作者：

ALLISON, BA ^{[1
]}

PRITCHARD, PH ^{[1
]}

RICHTER, AM ^{[1
]}

LEVY, JG ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PATHOL,VANCOUVER V6T 1W5,BC,CANADA

来源：

PHOTOCHEMISTRY AND PHOTOBIOLOGY | 1990年 / 52卷 / 03期

关键词：

D O I：

10.1111/j.1751-1097.1990.tb01792.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Abstract— The plasma distribution and biodistribution of benzoporphyrin derivative were examined. Two analogs of benzoporphyrin derivative were mixed with human plasma in vitro and recovered in the lipoprotein fractions upon separation by chromatography or ultracentrifugation. The majority of both analogs was recovered with high density lipoprotein. The effect of prebinding benzoporphyrin derivative to lipoproteins on the biodistribution of the drug in vivo was studied in tumor bearing DBA/2J mice. At 3, 8 and 24 h post‐injection, tumor and tissue samples were excised and analyzed for benzoporphyrin derivative content. Precomplexing benzoporphyrin derivative with low density lipoprotein or high density lipoprotein led to significantly (P < 0.05) greater tumor accumulation than in aqueous solution. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：501 / 507

页数：7

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