FLUID-FLOW AND PLAQUE-FORMATION IN AN AORTIC BIFURCATION

被引:34
作者
NAZEMI, M [1 ]
KLEINSTREUER, C [1 ]
ARCHIE, JP [1 ]
SORRELL, FY [1 ]
机构
[1] N CAROLINA STATE UNIV,DEPT MECH & AEROSP ENGN,RALEIGH,NC 27695
来源
JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 1989年 / 111卷 / 04期
关键词
D O I
10.1115/1.3168385
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Considering steady laminar flow in a two-dimensional symmetric branching channel with local occlusions, a finite element model has been developed to study velocity fields including reverse flow regions, pressure profiles and wall shear stress distributions for different Reynolds numbers, bifurcation angles and lumen reductions. The flow analysis has been extended to include a new submodel for the pseudo-transient formation of plaque at sites and deposition rates defined by the physical characteristics of the flow. Specifically, simulating the onset of atherosclerotic lesions, sinusoidal plaque layers have been placed in areas of critically low wall shear stresses, and simulating the growth of particle depositions, plaque layers have been added in a stepwise fashion in regions of critically high and low shear. Thus two somewhat conflicting hypothetical correlations between critical wall shear stress levels and atheroma have been tested and a solution has been postulated. The validated computer simulation model is a predictive tool for analyzing the effects of local changes in wall curvature due to surgical reconstruction and/or atherosclerotic lesions, and for investigating the design of aortic bifurcations which mitigate plaque formation.
引用
收藏
页码:316 / 324
页数:9
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