INDUCTION OF PREGNANCY-ASSOCIATED MURINE PROTEIN-1 IN DWARF MICE BY HUMAN GROWTH-HORMONE

被引：3

作者：

HAU, J

POULSEN, OM

HANSEN, NFD

WORM, KR

机构：

[1] Department of Veterinary Pathology, Laboratory Animal Unit, The Royal Veterinary and Agricultural University, 1870 Frederiksberg C, Copenhagen

来源：

LABORATORY ANIMALS | 1990年 / 24卷 / 02期

关键词：

Human Growth Hormone; Pregnancy-Associated Murine Protein-1; Snell Dwarf Mice;

D O I：

10.1258/002367790780890158

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Pregnancy-associated murine protein-1 (PAMP-1) could not be detected in peripheral blood of female dwarf mice (genotype dw/dw of the DW strain). By contrast the normal size females of the DW strain (genotypes +/+ and +/dw) had PAMP-1 serum levels of 18·9 AU ± 15·7 AU/ml. Following administration of biosynthetic human growth hormone (hGH) every 2h for 52 h PAMP-1 was detected in all dwarf females at concentrations of 16·0 AU ± 3·3 AU/ml. The albumin levels in the circulation of DW females of normal size were significantly higher (P<0·05) than those of DW dwarfs, and the hGH administration did not change the serum albumin levels. The present experiment adds weight to the suggestion that the PAMP-1 serum level is regulated by GH. © 1990, Royal Society of Medicine Press. All rights reserved.

引用

页码：183 / 186

页数：4

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