SPONTANEOUS CHEMILUMINESCENCE ACTIVITY OF PERIPHERAL-BLOOD CELLS DURING EXPERIMENTAL ALLERGIC NEURITIS (EAN)

被引：7

作者：

STEVENS, A ^{[1
]}

LANG, R ^{[1
]}

SCHABET, M ^{[1
]}

WIETHOLTER, H ^{[1
]}

HAMMANN, K ^{[1
]}

机构：

[1] UNIV MAINZ,DEPT NEUROL,W-6500 MAINZ,GERMANY

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 27卷 / 01期

关键词：

Experimental allergic neuritis; Monocyte; Reactive oxygen intermediate; Spontaneous chemiluminescence;

D O I：

10.1016/0165-5728(90)90133-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In 30 Lewis rats the time course of spontaneous monocyte and granulocyte chemiluminescence activity (CLA) during myelin-induced experimental allergic neuritis (EAN) was studied. CLA of blood and peritoneal cells, and clinical, histopathological and electrophysiological findings were compared with data from 14 animals immunized with complete Freund's adjuvant and ten normal Lewis rats. About 12 days post-immunization there was a significant (p < 0.003) rise in monocyte, but not in granulocyte CLA in EAN animals. CLA correlated significantly (p < 0.02) with infiltrate formation in nerve roots, preceding clinical or electrophysiological signs of disease by 1-2 days. There was no increase in peritoneal monocyte CLA, which was consistently higher than blood monocyte CLA (p < 0.002). © 1990.

引用

页码：33 / 40

页数：8

共 33 条

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