DEVELOPMENT OF L-689,065 - THE PROTOTYPE OF A NEW CLASS OF POTENT 5-LIPOXYGENASE INHIBITORS

被引：14

作者：

HUTCHINSON, JH

PRASIT, P

CHOO, LY

RIENDEAU, D

CHARLESON, S

EVANS, JF

PIECHUTA, H

BALL, RG

机构：

[1] Medicinal Chemistry, Rahway, NJ

[2] Biochemistry, Rahway, NJ

[3] Pharmacology, Rahway, NJ

[4] Biophysical Chemistry, Rahway, NJ

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1992年 / 2卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(00)80459-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The combination of a 5-phenylpyridine substituent and a novel, substituted thiopyrano[2,3,4-c,d]indole ring system yields a potent and selective 5-lipoxygenase inhibitor, L-689,065.

引用

页码：1699 / 1702

页数：4

共 16 条

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