HISTAMINE-INDUCED, CENTRAL NERVOUS SYSTEM-MEDIATED HYPERGLYCEMIA IS SUPPRESSED BY ATROPINE IN THE BRAIN

被引：2

作者：

NONOGAKI, K

LI, XZ

TAMAGAWA, T

WATANABE, G

HIYOSHI, Y

OZAWA, K

SAKAMOTO, N

IGUCHI, A

机构：

来源：

LIFE SCIENCES | 1993年 / 52卷 / 15期

关键词：

D O I：

10.1016/0024-3205(93)90096-L

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the relationship between histamine and muscarinic cholinergic neurons in central nervous system (CNS)-mediated glucose regulation in anesthetized fed rats. The injection of pyrilamine (5x10(-7) mol) into the third cerebral ventricle suppressed the hyperglycemia induced by intraventricular injection of histamine (5x10(-7) mol). Ranitidine (5x10(-7) mol), however, did not suppress this hyperglycemia. The injection of atropine (5x10(-9)-5x10(-7) mol) into the third cerebral ventricle suppressed the histamine-induced hyperglycemia in a dose-dependent manner. These findings suggest that histamine induction of CNS-mediated hyperglycemia involves neuronal transmission not only via H-1 receptors but also, at least in part, by muscarinic cholinergic neurons.

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页码：PL107 / PL110

页数：4

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