MOLECULAR-CLONING OF OLFACTOMEDIN, AN EXTRACELLULAR-MATRIX PROTEIN-SPECIFIC TO OLFACTORY NEUROEPITHELIUM

被引：105

作者：

YOKOE, H ^{[1
]}

ANHOLT, RRH ^{[1
]}

机构：

[1] DUKE UNIV,MED CTR,DEPT NEUROBIOL,BOX 3209,DURHAM,NC 27710

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1993年 / 90卷 / 10期

关键词：

CHEMORECEPTION; OLFACTION; MUCUS; NEURONAL GROWTH;

D O I：

10.1073/pnas.90.10.4655

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The extracellular mucous matrix of olfactory neuroepithelium is a highly organized structure in intimate contact with chemosensory cilia that house the olfactory transduction machinery. Here we describe the molecular cloning and primary structure of olfactomedin, which is the major component of this extracellular matrix. Olfactomedin is expressed exclusively in olfactory neuroepithelium and its amino acid sequence shows no homologies to any known protein. This olfactory tissue-specific glycoprotein contains cysteines which form disulfide-linked polymers that constitute the primary architecture of the olfactory extracellular matrix. By analogy to other extracellular matrix proteins of the nervous system, olfactomedin may influence the maintenance, growth, or differentiation of chemosensory cilia on the apical dendrites of olfactory neurons.

引用

页码：4655 / 4659

页数：5

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