ATTENUATION OF AUTOIMMUNE-DISEASE AND LYMPHOCYTE ACCUMULATION IN MRL/LPR MICE BY TREATMENT WITH ANTI-V-BETA-8 ANTIBODIES

被引：26

作者：

DEALBORAN, IM ^{[1
]}

GONZALO, JA ^{[1
]}

KROEMER, G ^{[1
]}

LEONARDO, E ^{[1
]}

MARCOS, MAR ^{[1
]}

MARTINEZ, C ^{[1
]}

机构：

[1] UNIV AUTONOMA MADRID, CTR BIOL MOLEC, CSIC, CAMPUS CANTOBLANCO, E-28049 MADRID, SPAIN

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1992年 / 22卷 / 08期

关键词：

D O I：

10.1002/eji.1830220829

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

MRL-MP-lpr/lpr mice are afflicted by a severe systemic autoimmune disease that is aggravated by the lpr mutation resulting in the accumulation of phenotypically abnormal lpr cells (CD3+CD4-CD8-) in all lymphoid issues including hyperplastic lymph nodes. Given that products of the T cell receptor V(beta)8 gene family are overrepresented among lpr cells. different schedules aimed at selectively decreasing the frequency of lpr cells were designed. First, continuous administration of the monoclonal antibody F23.1 (specific for V(beta)8 products) resulted in a significant depletion of V(beta)8+ cells and prevented the manifestation of lymph accumulation at the same time as it reduced the serological, clinical, and histopathological signs of autoimmune disease. Along the same line, administration of either F23.1 or two different anti-F23.1 anti-idiotypic antibodies to MRL/Mp-lpr/lpr mothers elicited, in the off spring, the production of antibodies sharing a recurrent idiotype with F23.1 and resulted in long-term amelioration of autoimmunity and lymphadenopathy Thus, a strategy aimed at specifically reducing the frequency of a subset of lpr cells proved successful in mitigating the autoimmune process.

引用

页码：2153 / 2158

页数：6

共 39 条

[1] LIMITED HETEROGENEITY OF T-CELL RECEPTORS FROM LYMPHOCYTES MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS ALLOWS SPECIFIC IMMUNE INTERVENTION [J].

ACHAORBEA, H ;

MITCHELL, DJ ;

TIMMERMANN, L ;

WRAITH, DC ;

TAUSCH, GS ;

WALDOR, MK ;

ZAMVIL, SS ;

MCDEVITT, HO ;

STEINMAN, L .

CELL, 1988, 54 (02) :263-273

[2] JUNCTIONAL REGION SEQUENCES OF T-CELL RECEPTOR BETA-CHAIN GENES EXPRESSED BY PATHOGENIC ANTI-DNA AUTOANTIBODY-INDUCING HELPER T-CELLS FROM LUPUS MICE - POSSIBLE SELECTION BY CATIONIC AUTOANTIGENS [J].

ADAMS, S ;

LEBLANC, P ;

DATTA, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11271-11275

[3] IMMUNE NETWORKS - FREQUENCIES OF ANTIBODY-PRODUCING AND IDIOTYPE-PRODUCING B-CELL CLONES IN VARIOUS STEADY-STATES [J].

BERNABE, RR ;

COUTINHO, A ;

MARTINEZ, C ;

CAZENAVE, PA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1981, 154 (02) :552-556

[4] SUPPRESSION OF A RECURRENT IDIOTYPE RESULTS IN PROFOUND ALTERATIONS OF THE WHOLE B-CELL COMPARTMENT [J].

BERNABE, RR ;

COUTINHO, A ;

CAZENAVE, PA ;

FORNI, L .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1981, 78 (10) :6416-6420

[5] THERAPY AGAINST MURINE COLLAGEN-INDUCED ARTHRITIS WITH T-CELL RECEPTOR V-BETA-SPECIFIC ANTIBODIES [J].

CHIOCCHIA, G ;

BOISSIER, MC ;

FOURNIER, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1991, 21 (12) :2899-2905

[6] LPR AND GLD - SINGLE GENE MODELS OF SYSTEMIC AUTOIMMUNITY AND LYMPHOPROLIFERATIVE DISEASE [J].

COHEN, PL ;

EISENBERG, RA .

ANNUAL REVIEW OF IMMUNOLOGY, 1991, 9 :243-269

[7] LPR T-CELLS VACCINATE AGAINST LUPUS IN MRL/LPR MICE [J].

DEALBORAN, IM ;

GUTIERREZ, JC ;

GONZALO, JA ;

ANDREU, JL ;

MARCOS, MAR ;

KROEMER, G ;

MARTINEZA, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1992, 22 (04) :1089-1093

[8] PREVENTION OF VACCINIA VIRUS-INFECTION IN IMMUNODEFICIENT MICE BY VECTOR-DIRECTED IL-2 EXPRESSION [J].

FLEXNER, C ;

HUGIN, A ;

MOSS, B .

NATURE, 1987, 330 (6145) :259-262

[9]

FUKUDA M, 1989, DIABETES, V38, P12

[10] SELECTIVE EXPANSION OF IDIOTYPE SHARING T-CELLS AND B-CELLS IN CYCLOSPORINE-A-MEDIATED AUTOIMMUNITY [J].

GASPAR, ML ;

MARCOS, MAR ;

PEREIRA, P ;

TORIBIO, ML ;

COUTINHO, A ;

MARTINEZA, C .

INTERNATIONAL IMMUNOLOGY, 1991, 3 (08) :777-784

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