ANTIEPILEPTIC EFFECTS OF INHIBITORS OF NITRIC-OXIDE SYNTHASE EXAMINED IN PENTYLENETETRAZOL-INDUCED SEIZURES IN RATS

被引：139

作者：

OSONOE, K ^{[1
]}

MORI, N ^{[1
]}

SUZUKI, K ^{[1
]}

OSONOE, M ^{[1
]}

机构：

[1] FUKUSHIMA MED COLL,DEPT NEUROPSYCHIAT,FUKUSHIMA 96012,JAPAN

来源：

BRAIN RESEARCH | 1994年 / 663卷 / 02期

关键词：

NITRIC OXIDE; PENTYLENETETRAZOL; N-G-METHYL-ARGININE; N-OMEGA-INTRO-L-ARGININE; EPILEPSY; RAT;

D O I：

10.1016/0006-8993(94)91283-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effects of intraperitoneal N-G-methyl-L-arginine and N-omega-nitro-L-arginine methyl ester, specific inhibitors of nitric oxide (NO) synthase, were examined on the pentylenetetrazol (PTZ)-induced seizures in rats. The incidence and latency for the onset of myoclonic jerks, clonic seizures, and tonic generalized extension were observed as specific parameters among PTZ-induced seizures. Both drugs preferentially suppressed the tonic generalized extension and prolonged the latency for the onset of each parameter, suggesting NO has a significant effect on the PTZ-induced seizure.

引用

页码：338 / 340

页数：3

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