Interaction of ascorbic acid with the neurotoxic effects of NMDA and sodium nitroprusside

被引：16

作者：

Bell, JA

Beglan, CL

London, ED

机构：

[1] NIDA,INTRAMURAL RES PROGRAM,NEUROIMAGING & DRUG ACT SECT,BALTIMORE,MD 21224

[2] JOHNS HOPKINS UNIV,SCH MED,DEPT RADIOL,BALTIMORE,MD 21205

[3] UNIV MARYLAND,SCH MED,DEPT PHARMACOL & EXPTL THERAPEUT,BALTIMORE,MD 21205

来源：

LIFE SCIENCES | 1995年 / 58卷 / 04期

关键词：

neurons; NMDA; neurotoxicity; nitric oxide; neuroprotection;

D O I：

10.1016/0024-3205(95)02296-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We have previously shown that ascorbic acid (AA) protects cortical neurons in culture from the toxic effects of NMDA. In the present study, we examined the interactions of AA with toxicity produced by nitric oxide (NO) that is generated from the breakdown of sodium nitroprusside (SNP), and with NMDA toxicity measured 24 h later. AA enhanced SNP toxicity, but it reduced toxicity of NMDA. We propose that these data support a model wherein AA produces neuroprotection by an action at the NMDA receptor, and indirectly with respect to NO. This effect occurs probably by antagonizing Ca2+ influx starting the cascade of biochemical events that lead to the production of NO.

引用

页码：367 / 371

页数：5

共 9 条

[1] NITRIC-OXIDE GENERATION FROM NITROPRUSSIDE BY VASCULAR TISSUE - EVIDENCE THAT REDUCTION OF THE NITROPRUSSIDE ANION AND CYANIDE LOSS ARE REQUIRED [J].