PHARMACOKINETICS OF FENBUFEN IN MAN

被引：16

作者：

CUISINAUD, G ^{[1
]}

LEGHEAND, J ^{[1
]}

LLORCA, G ^{[1
]}

BELKAHIA, C ^{[1
]}

LEJEUNE, E ^{[1
]}

SASSARD, J ^{[1
]}

机构：

[1] HOP CHARPENNES,RHEUMATISM SERV,LYON,FRANCE

来源：

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY | 1979年 / 16卷 / 01期

关键词：

antiinflammantory agents; fenbufen; human pharmacokinetics; metabolites;

D O I：

10.1007/BF00644968

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The pharmacokinetics of fenbufen (3.4-biphenylylcarbonyl propionic acid) a new antiinflammatory agent, and its metabolites, γ-hydroxy-4-biphenylbutyric acid and 4-biphenylacetic acid have been studied after oral administration to seven patients with rheumatoid arthritis. Fenbufen was administered as a single oral dose of 600 mg in hard gelatine capsules. A specific, sensitive gas chromatographic method was used to measure the concentration of the three compounds. A linear two-compartment open model appeared suitable to describe the course of the plasma level of fenbufen with time. This compound appeared in the blood after a lag time of 0.45 h and the peak plasma concentration of 5.97 μg/ml was observed after 1.19 h. The half-life of plasma disappearance was 10.26 h for fenbufen and 10.07 h and at 9.95 h for metabolites II and III, respectively. © 1979 Springer-Verlag.

引用

页码：59 / 61

页数：3

共 11 条

[1] FENBUFEN, A NEW ANTI-INFLAMMATORY ANALGESIC - SYNTHESIS AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF ANALOGS [J].