OROSOMUCOID IN HUMAN-PREGNANCY SERUM DIMINISHES BIOAVAILABILITY OF THE PROGESTERONE ANTAGONIST RU-486 IN RATS

被引：5

作者：

STEINGOLD, KA ^{[1
]}

MATT, DW ^{[1
]}

DUA, L ^{[1
]}

ANDERSON, TL ^{[1
]}

HODGEN, GD ^{[1
]}

机构：

[1] EASTERN VIRGINIA MED SCH,JONES INST REPROD MED,DEPT OBSTET & GYNECOL,NORFOLK,VA 23501

来源：

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | 1990年 / 162卷 / 02期

关键词：

orosomucoid; pregnancy; pregnancy termination; Progesterone antagonist; RU; 486; serum α[!sub]1[!/sub]-acid glycoprotein;

D O I：

10.1016/0002-9378(90)90422-4

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Bioavailability of the progesterone antagonist RU 486 was examined in vivo by measurement of first-pass uptake by hepatic and uterine tissues in rats. Presence of human pregnancy serum or α1-acid glycoprotein (orosomucoid) in injection vehicles diminished uptake of this steroid, which suggests limited bioavailability. These data indicate that elevated human serum orosomucoid levels may account for some failures of RU 486 in early pregnancy termination. © 1990.

引用

页码：523 / 524

页数：2