EFFECTS OF BUTENAFINE HYDROCHLORIDE, A NEW BENZYLAMINE DERIVATIVE, ON EXPERIMENTAL DERMATOPHYTOSIS IN GUINEA-PIGS

被引：44

作者：

ARIKA, T ^{[1
]}

YOKOO, M ^{[1
]}

HASE, T ^{[1
]}

MAEDA, T ^{[1
]}

AMEMIYA, K ^{[1
]}

YAMAGUCHI, H ^{[1
]}

机构：

[1] TEIKYO UNIV,MED MYCOL RES CTR,TOKYO 19203,JAPAN

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1990年 / 34卷 / 11期

关键词：

D O I：

10.1128/AAC.34.11.2250

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Butenafine hydrochloride, N-4-tert-butylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride (butenafine), is a novel antifungal agent of the class of benzylamine derivatives. Butenafine was investigated for its activity against guinea pig dermatophytosis caused by Trichophyton mentagrophytes or Microsporum canis in comparison with those of naftifine, tolnaftate, clotrimazole, and bifonazole. Topical butenafine showed excellent efficacy against dermatophytosis when it was applied once daily, and the effect was superior to those of all four reference drugs. When applied once at 24 or 48 h before infection, the drug exhibited excellent prophylactic efficacy against experimental T. mentagrophytes infection. The concentrations of butenafine in animal skin at 24 and 48 h after application of 0.2 ml of a 1% solution were several hundred times higher than those required to kill T. mentagrophytes and M. canis. The good efficacy of butenafine against dermatophytosis may be attributable to its fungicidal activity and long retention in the skin after topical application.

引用

页码：2250 / 2253

页数：4

共 12 条

[1] INVITRO ACTIVITY OF NAFTIFINE, A NEW ANTIFUNGAL AGENT [J].