A PRACTICAL ACCESS TO OPTICALLY PURE (S)-1-OCTYN-3-OL

被引：17

作者：

HASHIMOTO, S ^{[1
]}

KASE, S ^{[1
]}

SUZUKI, A ^{[1
]}

YANAGIYA, Y ^{[1
]}

IKEGAMI, S ^{[1
]}

机构：

[1] TEIKYO UNIV,FAC PHARMACEUT SCI,SAGAMIKO,KANAGAWA 19901,JAPAN

来源：

SYNTHETIC COMMUNICATIONS | 1991年 / 21卷 / 06期

关键词：

D O I：

10.1080/00397919108019765

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly efficient resolution of (+/-)-1-octyn-3-ol through recrytallization of the diastereomeric esters has been achieved by using N-(p-toluenesulfonyl)-(S)-phenylalanyl chloride as resolving reagent. The method provides a facile and economical entry to (S)-1-octyn-3-ol, a valuable building block for the synthesis of arachidonic acid metabolites.

引用

页码：833 / 839

页数：7

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