EFFECTS OF PROTON PUMP INHIBITOR ON GASTRIC-MUCOSA HEMODYNAMICS AND TISSUE OXYGENATION IN ANESTHETIZED RATS

被引：16

作者：

KAWANO, S ^{[1
]}

TANIMURA, H ^{[1
]}

SATO, N ^{[1
]}

TSUJI, S ^{[1
]}

TAKEI, Y ^{[1
]}

OGIHARA, T ^{[1
]}

NAGANO, K ^{[1
]}

FUSAMOTO, H ^{[1
]}

KAMADA, T ^{[1
]}

机构：

[1] JUNTENDO UNIV, SCH MED, DEPT GASTROENTEROL, BUNKYO KU, TOKYO 113, JAPAN

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 211卷 / 01期

关键词：

PROTON PUMP INHIBITORS; GASTRIC MUCOSA BLOOD VOLUME; GASTRIC MUCOSA OXYGENATION; REFLECTANCE SPECTROPHOTOMETRY; HEMORRHAGIC SHOCK; OMEPRAZOLE; NC-1300;

D O I：

10.1016/0014-2999(92)90262-3

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Proton pump inhibitors have been reported to have a cytoprotective action in addition to the anti-secretory action of acid. The precise mechanism, however, remains obscure. In this study, the effects of proton pump inhibitors (omeprazole and NC-1300) on gastric mucosa hemodynamics and tissue oxygenation were investigated using organ reflectance spectrophotometry in a hemorrhagic shock-reperfusion model involving anesthetized rats. Neither drug affected gastric mucosa hemodynamics nor tissue oxygenation in the basal state before hemorrhage. During the hemorrhagic shock state, however, these drugs maintained tissue oxygenation and reduced ulcer formation, although they did not show a significant effect on gastric mucosa blood volume. The results suggest that both proton pump inhibitors have an anti-ulcer action by maintaining mucosal oxygenation in addition to the anti-secretory activity of acid.

引用

页码：55 / 60

页数：6

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