2-STEP HYDROLYZES OF A POLYMERIC DRUG UNDER A MODEL SYSTEM

被引：8

作者：

TOKURA, S ^{[1
]}

KANEDA, Y ^{[1
]}

MIURA, Y ^{[1
]}

URAKI, Y ^{[1
]}

机构：

[1] HOKKAIDO UNIV,FAC AGR,DEPT FOREST SCI,SAPPORO,HOKKAIDO 060,JAPAN

来源：

CARBOHYDRATE POLYMERS | 1992年 / 19卷 / 03期

关键词：

D O I：

10.1016/0144-8617(92)90160-R

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

Model polymeric drugs were synthesized by using 6-O-carboxymethyl-chitin as a biodegradable carrier and several peptides as spacer. The release of drug (chromogenic compound) was not observed by chymotrypsin-catalyzed hydrolysis until the proper size of oligomeric drug (prodrug) was produced predominantly by lysozymic hydrolysis. The amino-acid composition of the spacer and the spacer length were found to be preliminary regulation factors for two-step hydrolysis of the polymeric drug.

引用

页码：185 / 190

页数：6

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