ADENYL CYCLASE ACTIVITY IN HUMAN PLATELETS

被引：207

作者：

WOLFE, SM

SHULMAN, NR

机构：

[1] Metabolic Diseases, Branches National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, MD

[2] Clinical Hematology, Branches National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda, MD

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 35卷 / 02期

关键词：

D O I：

10.1016/0006-291X(69)90277-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adenyl cyclase activity has been demonstrated in washed particles from ultrasonically disrupted platelets. NaF increased activity 10-fold and prostaglandin (PGE1) increased activity 18-fold. This is the first time a substance other than NaF has caused maximal stimulation of adenyl cyclase. Activation was found with PGE1 concentrations below 10-8M. The inhibitory effect of PGE1 on platelet aggregation may be related to activation of adenyl cyclase. © 1969.

引用

页码：265 / &

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