POSSIBLE ROLE OF GLUTATHIONE IN MAINTAINING HUMAN LENS PROTEIN SULFHYDRYLS

被引：44

作者：

AUGUSTEYN, RC ^{[1
]}

机构：

[1] UNIV MELBOURNE, RUSSELL GRIMWADE SCH BIOCHEM, PARKVILLE 3052, VICTORIA, AUSTRALIA

来源：

EXPERIMENTAL EYE RESEARCH | 1979年 / 28卷 / 06期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

glutathione; human lens protein sulphydryl; nuclear cataract;

D O I：

10.1016/0014-4835(79)90067-8

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glutathione can cleave the disulphide bonds in proteins from advanced nuclear cataractous lenses and in mixed disulphides of lens proteins and glutathione. The equilibrium constants for these reactions were estimated to be 0.02-0.05 and 0.07, respectively. Endogenous glutathione can protect lens protein sulphydryl groups from oxidation in vitro, provided NADPH2 and G-6-P are added.

引用

页码：665 / 671

页数：7

共 9 条

[1] STATE OF SULFHYDRYL-GROUPS IN NORMAL AND CATARACTOUS HUMAN LENS PROTEINS .1. NUCLEAR REGION [J].

ANDERSON, EI ;

SPECTOR, A .

EXPERIMENTAL EYE RESEARCH, 1978, 26 (04) :407-417

[2] STUDIES ON THE OXIDATION OF CYSTEINE TO CYSTINE IN LENS PROTEINS DURING CATARACT FORMATION [J].

DISCHE, Z ;

ZIL, H .

AMERICAN JOURNAL OF OPHTHALMOLOGY, 1951, 34 (05) :104-113

[3] THE EQUILIBRIUM CONSTANTS AND OXIDATION-REDUCTION POTENTIALS OF SOME THIOL-DISULFIDE SYSTEMS [J].

ELDJARN, L ;

PIHL, A .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1957, 79 (17) :4589-4593

[4] DISULFIDE CROSSLINKED PROTEIN OF HIGH MOLECULAR-WEIGHT IN HUMAN CATARACTOUS LENS [J].

HARDING, JJ .

EXPERIMENTAL EYE RESEARCH, 1973, 17 (04) :377-383

[5]

KINOSHITA JH, 1964, ARCH OPHTHALMOL-CHIC, V72, P554

[6] GLUTATHIONE REDUCTASE IN NORMAL AND CATARACTOUS HUMAN LENSES [J].

ROGERS, KM ;

AUGUSTEYN, RC .

EXPERIMENTAL EYE RESEARCH, 1978, 27 (06) :719-721

[7] CLEAVAGE OF LENS PROTEIN-GSH MIXED DISULFIDE BY GLUTATHIONE REDUCTASE [J].

SRIVASTAVA, SK ;

BEUTLER, E .

EXPERIMENTAL EYE RESEARCH, 1973, 17 (01) :33-42

[8] STATE OF SULFHYDRYL-GROUPS IN NORMAL AND CATARACTOUS HUMAN LENSES [J].

TRUSCOTT, RJW ;

AUGUSTEYN, RC .

EXPERIMENTAL EYE RESEARCH, 1977, 25 (02) :139-148

[9] CHANGES IN HUMAN LENS PROTEINS DURING NUCLEAR CATARACT FORMATION [J].

TRUSCOTT, RJW ;

AUGUSTEYN, RC .

EXPERIMENTAL EYE RESEARCH, 1977, 24 (02) :159-170

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