ENDOGENOUS PROSTAGLANDIN-E2 SYNTHESIS INHIBITS GROWTH OF POLYOMA VIRUS-TRANSFORMED 3T3 FIBROBLASTS

被引：17

作者：

LINDGREN, JA

CLAESSON, HE

HAMMARSTROM, S

机构：

[1] Department of Chemistry, Karolinska Institutet

来源：

EXPERIMENTAL CELL RESEARCH | 1979年 / 124卷 / 01期

关键词：

D O I：

10.1016/0014-4827(79)90250-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Indomethacin lowered the cellular content of adenosine 3 ′: 5 ′-monophosphate (cAMP) and stimulated growth of polyoma virus-transformed 3T3 fibroblasts. Exogenous prostaglandin E2, at concentrations produced in the absence of inhibitor, reversed the effects of indomethacin on cAMP levels and cell proliferation. Therefore, endogenously produced prostaglandin E2 decreases cell growth and raises the levels of cAMP in these cells. © 1979.

引用

页码：1 / 5

页数：5

共 15 条

[1]

BURTON K, 1956, ANAL BIOCHEM, V59, P63

[2] PROSTAGLANDIN-E-2 PRODUCTION IN 3T3-CELLS TRANSFORMED BY POLYOMA-VIRUS RAISES INTRACELLULAR ADENOSINE 3'=5'-MONOPHOSPHATE LEVELS [J].