EFFECT OF PHORBOL-MYRISTATE ACETATE ON PROCESSING OF FORMYL PEPTIDE RECEPTORS BY HUMAN NEUTROPHILS

被引：4

作者：

LOBO, E

ELFMAN, F

KELLY, E

PEREZ, HD

机构：

[1] SAN FRANCISCO GEN HOSP,BLDG 30,ROOM 3300,1001 POTRERO AVE,SAN FRANCISCO,CA 94110

[2] UNIV CALIF SAN FRANCISCO,ROSALIND RUSSELL ARTHRITIS RES LABS,SAN FRANCISCO,CA 94143

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1990年 / 1055卷 / 02期

关键词：

(Human); N-Formyl peptide receptor; Neutrophil; Phorbol myristate acetate; Receptor recycling; Receptor regulation;

D O I：

10.1016/0167-4889(90)90122-T

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We examined the effect of phorbol myristate acetate on the ability of human neutrophils to process formyl peptide receptors. The receptor was affinity-labeled and its extracellular localization assessed over time, by cleavage of extracellular labeled receptor with papain. Neutrophils were capable of internalizing (and/or recycling) affinity labeled formyl peptide receptor in the absence of extracellular calcium. This phenomenon was dependent upon stimulation with phorbol myristate acetate, suggesting a role for protein kinase C in this process. © 1990.

引用

页码：193 / 196

页数：4

共 10 条

[1]

DOLMATCH B, 1983, J BIOL CHEM, V258, P7570

[2]

HUECKSTEADT T, 1986, J BIOL CHEM, V261, P8655

[3] THE OLIGOPEPTIDE CHEMOTACTIC FACTOR RECEPTOR ON HUMAN POLYMORPHONUCLEAR LEUKOCYTE MEMBRANES EXISTS IN 2 AFFINITY STATES [J].