PORCINE MODEL FOR STUDYING THE PASSAGE OF NONDEPOLARIZING NEUROMUSCULAR BLOCKERS THROUGH THE BLOOD-BRAIN-BARRIER

被引：10

作者：

WERBA, A

GILLY, H

WEINDLMAYRGOETTEL, M

SPISS, CK

STEINBEREITHNER, K

CZECH, T

AGOSTON, S

机构：

[1] LUDWIG BOLTZMANN INST EXPTL ANAESTHESIOL & RES INTENS CARE MED,A-1090 VIENNA,AUSTRIA

[2] UNIV VIENNA,NEUROSURG CLIN,A-1090 VIENNA,AUSTRIA

[3] UNIV GRONINGEN,EXPTL ANESTHESIOL & CLIN PHARMACOL RES GRP,9713 EZ GRONINGEN,NETHERLANDS

来源：

BRITISH JOURNAL OF ANAESTHESIA | 1992年 / 69卷 / 04期

关键词：

BRAIN; BLOOD BRAIN BARRIER; CEREBROSPINAL FLUID; DRUG TRANSFER; NEUROMUSCULAR RELAXANTS; PANCURONIUM;

D O I：

10.1093/bja/69.4.382

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

A method has been developed for blood-brain barrier disruption to provide reproducible access to the cerebrospinal fluid of the cerebellomedullary cistern. The technique was used successfully to investigate transfer of pancuronium to the cerebral CSF compartment in pigs. After osmotic disruption of the blood-brain barrier, pancuronium concentrations increased significantly in the cerebrospinal fluid.

引用

页码：382 / 386

页数：5

共 16 条

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Davson H., 1984, HYDROCEPHALUS, P3

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