SECRETION OF PRORENIN BY A VIRILIZING OVARIAN TUMOR

被引：16

作者：

ANDERSON, PW

DABLAING, G

PENNY, R

SHERROD, A

DO, YS

机构：

[1] UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT PEDIAT, LOS ANGELES, CA 90033 USA

[2] UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT PATHOL, LOS ANGELES, CA 90033 USA

[3] NORRIS CANC CTR HOSP, LOS ANGELES, CA 90033 USA

[4] UNIV SO CALIF, LOS ANGELES CTY MED CTR, DEPT INTERNAL MED, LOS ANGELES, CA 90033 USA

来源：

GYNECOLOGIC ONCOLOGY | 1992年 / 45卷 / 01期

关键词：

D O I：

10.1016/0090-8258(92)90491-Z

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A-53-year-old normotensive, normokalemic female presented with a 6-month history of virilization. Estradiol, LH, FSH, urinary-free cortisol, and DHEA-S levels were normal. Pelvic ultrasound and computerized tomography were also within normal limits. Her serum testosterone (551 ng/dl; nl, 20-70) and plasma prorenin (124 ng A1/ml/hr; nl, < 50) levels were elevated. At surgery, a lipoid/ steroid cell tumor of the right ovary was removed. Postoperative testosterone and prorenin levels were normal. Ovarian tumor cells, in culture, produced large amounts of prorenin. Immunohistochemistry localized prorenin and/or renin to tumor cells. Determining plasma prorenin levels may be a useful adjunct in diagnosing or following patients with nonepithelial ovarian tumors. A larger clinical study of prorenin levels in patients with such tumors is needed. © 1992.

引用

页码：58 / 61

页数：4

共 16 条

[1] EXTRARENAL RENIN-SECRETING TUMORS - INSIGHTS INTO HYPERTENSION AND OVARIAN RENIN PRODUCTION [J].