SYNTHESIS, CHEMICAL-REACTIVITY, AND CYTOTOXICITY OF 2-BIS(ALKOXYCARBONYL)METHYLIDEN-1-AZABICYCLO[3.1.0]HEXANE SYSTEMS RELATED TO ANTITUMOR ANTIBIOTIC CARZINOPHILIN-A

被引：22

作者：

HASHIMOTO, M ^{[1
]}

YAMADA, K ^{[1
]}

TERASHIMA, S ^{[1
]}

机构：

[1] SAGAMI CHEM RES CTR, SAGAMIHARA, KANAGAWA 229, JAPAN

来源：

CHEMISTRY LETTERS | 1992年 / 06期

关键词：

D O I：

10.1246/cl.1992.975

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Enantiomeric pairs of the title compounds were synthesized starting from (S)- and (R)-pyroglutamic acid. They were found to be susceptible to nucleophilic ring opening of aziridine moieties and to exhibit weak in vitro cytotoxicity.

引用

页码：975 / 978

页数：4

共 14 条

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