STRUCTURAL ELUCIDATION OF ROKITAMYCIN, MIDECAMYCIN AND ERYTHROMYCIN METABOLITES FORMED BY PATHOGENIC NOCARDIA

被引：6

作者：

MORISAKI, N

IWASAKI, S

FURIHATA, K

YAZAWA, K

MIKAMI, Y

机构：

[1] UNIV TOKYO,FAC AGR,BUNKYO KU,TOKYO 113,JAPAN

[2] CHIBA UNIV,PATHOGEN FUNGI & MICROBIAL TOXICOSES RES CTR,CYUO KU,CHIBA 260,JAPAN

来源：

MAGNETIC RESONANCE IN CHEMISTRY | 1995年 / 33卷 / 06期

关键词：

MACROLIDE ANTIBIOTICS; METABOLITES; H-1; NMR; C-13; PATHOGENIC NOCARDIA;

D O I：

10.1002/mrc.1260330613

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Pathogenic Nocardia spp. converted rokitamycin, midecamycin and erythromycin into inactive metabolites, the structures of which were determined from NMR and mass spectral data. Depending on the species of Nocardia, these macrolides underwent phosphorylation at 2'-OH, hydrolysis of the 4''-O-acyl group, glycosylation at 2'-OH and/or reduction of the 18-formyl group. Full H-1 and C-13 assignments are presented and some solvent effects are described.

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页码：481 / 489

页数：9

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