RAPID AND SUBSTANTIAL LOWERING OF HUMAN-SERUM CHOLESTEROL BY MEVINOLIN (MK-803), AN INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME A REDUCTASE

被引:93
作者
TOBERT, JA
HITZENBERGER, G
KUKOVETZ, WR
HOLMES, IB
JONES, KH
机构
[1] VIENNA UNIV,MED 1 CLIN,DEPT CLIN PHARMACOL,A-1010 VIENNA,AUSTRIA
[2] UNIV GRAZ,INST PHARMACODYNAM & TOXICOL,A-8036 GRAZ,AUSTRIA
[3] MERCK SHARP & DOHME RES LABS,DEPT CLIN PHARMACOL,ZURICH,SWITZERLAND
关键词
D O I
10.1016/0021-9150(82)90070-3
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:61 / 65
页数:5
相关论文
共 12 条
  • [1] ACHOR RW, 1961, P STAFF M MAYO CLIN, V36, P217
  • [2] MEVINOLIN - A HIGHLY POTENT COMPETITIVE INHIBITOR OF HYDROXYMETHYLGLUTARYL-COENZYME-A REDUCTASE AND A CHOLESTEROL-LOWERING AGENT
    ALBERTS, AW
    CHEN, J
    KURON, G
    HUNT, V
    HUFF, J
    HOFFMAN, C
    ROTHROCK, J
    LOPEZ, M
    JOSHUA, H
    HARRIS, E
    PATCHETT, A
    MONAGHAN, R
    CURRIE, S
    STAPLEY, E
    ALBERSSCHONBERG, G
    HENSENS, O
    HIRSHFIELD, J
    HOOGSTEEN, K
    LIESCH, J
    SPRINGER, J
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (07): : 3957 - 3961
  • [3] AVIGAN J, 1960, J BIOL CHEM, V235, P3123
  • [4] A NOVEL MODE OF INHIBITION OF CHOLESTEROL BIOSYNTHESIS
    DVORNIK, D
    DUBUC, J
    GAUDRY, R
    KRAML, M
    GIVNER, M
    [J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1963, 85 (20) : 3309 - +
  • [6] ENDO A, 1977, EUR J BIOCHEM, V87, P313
  • [7] PREDISPOSITION TO ATHEROSCLEROSIS IN HEAD, HEART, AND LEGS - FRAMINGHAM STUDY
    GORDON, T
    KANNEL, WB
    [J]. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1972, 221 (07): : 661 - &
  • [8] TREATMENT OF HYPERCHOLESTEROLEMIA
    GRUNDY, SM
    [J]. AMERICAN JOURNAL OF CLINICAL NUTRITION, 1977, 30 (06) : 985 - 992
  • [9] KLOSE S, 1975, CLIN CHEM, V21, P942
  • [10] CATARACTS IN PATIENTS TREATED WITH TRIPARANOL
    LAUGHLIN, RC
    CAREY, TF
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1962, 181 (04): : 339 - &