INHIBITION OF GLYCOGEN-SYNTHASE KINASE-3 BY INSULIN IN CULTURED HUMAN SKELETAL-MUSCLE MYOBLASTS

被引：33

作者：

BORTHWICK, AC

WELLS, AM

ROCHFORD, JJ

HUREL, SJ

TURNBULL, DM

YEAMAN, SJ

机构：

[1] UNIV NEWCASTLE UPON TYNE,DEPT BIOCHEM & GENET,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

[2] UNIV NEWCASTLE UPON TYNE,DEPT CLIN NEUROSCI,NEWCASTLE TYNE NE2 4HH,TYNE & WEAR,ENGLAND

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1995年 / 210卷 / 03期

关键词：

D O I：

10.1006/bbrc.1995.1721

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The acute effects of insulin on the activity of glycogen synthase kinase 3 (GSK-3) have been investigated both in the rat L6 muscle cell line and in cultured human myoblasts, The alpha and beta isoforms of GSK-3 are present in both cell types,with the beta isoform being predominant in the human cells, insulin causes a rapid inactivation of both isoforms in both cell lines, with 50% inactivation being observed in the human myoblasts. (C) 1995 Academic Press, Inc.

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页码：738 / 745

页数：8

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