MOLECULAR STRUCTURE AND SOME TRANSPORT PROPERTIES OF VALINOMYCIN

被引：285

作者：

PINKERTON, M

STEINRAUF, LK

DAWKINS, P

机构：

[1] Department of Biochemistry Indiana University Medical School Indianapolis

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 35卷 / 04期

关键词：

D O I：

10.1016/0006-291X(69)90376-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antibiotic valinomycin is well known to affect the ion transport behavior of mitochondrial systems. We have determined the molecular structure by X-ray crystallography of this cyclododecadepsipeptide as the potassium aurichloride complex, and find it to be wrapped around the potassium ion coordinated to the oxygen atoms of alternate carbonyl groups, held together by hydrogen bonding, and holding the anion less specifically. We have constructed a diffusion apparatus with which the anion-cation transporting properties of valinomycin can be demonstrated. An equation is given for the equilibrium situation. © 1969.

引用

页码：512 / +

页数：1