ACTIVATION OF THE A10 MESOLIMBIC SYSTEM BY THE SIGMA-RECEPTOR AGONIST (+)SKF 10,047 CAN BE BLOCKED BY RIMCAZOLE, A NOVEL PUTATIVE ANTIPSYCHOTIC

被引：94

作者：

CECI, A

SMITH, M

FRENCH, ED

机构：

[1] UNIV ARIZONA,COLL MED,DEPT PHARMACOL,TUCSON,AZ 85724

[2] MARYLAND PSYCHIAT RES CTR,NEUROSCI PROGRAM,BALTIMORE,MD 21228

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1988年 / 154卷 / 01期

关键词：

D O I：

10.1016/0014-2999(88)90362-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

引用

页码：53 / 57

页数：5

共 17 条

[1] AN EARLY PHASE-II CLINICAL-TRIAL OF BW234U IN THE TREATMENT OF ACUTE SCHIZOPHRENIA IN NEWLY ADMITTED PATIENTS [J].

CHOUINARD, G ;

ANNABLE, L .

PSYCHOPHARMACOLOGY, 1984, 84 (02) :282-284

[2] AN ENDOGENOUS LIGAND FOR THE SIGMA-OPIOID BINDING-SITE [J].

CONTRERAS, PC ;

DIMAGGIO, DA ;

ODONOHUE, TL .

SYNAPSE, 1987, 1 (01) :57-61

[3]

DAVIDSON J, 1982, Psychopharmacology Bulletin, V18, P173

[4] RIMCAZOLE (BW U-234), A NOVEL ANTIPSYCHOTIC AGENT WHOSE MECHANISM OF ACTION CANNOT BE EXPLAINED BY A DIRECT BLOCKADE OF POSTSYNAPTIC DOPAMINERGIC RECEPTORS IN BRAIN [J].

FERRIS, RM ;

WHITE, HL ;

TANG, FLM ;

RUSSELL, A ;

HARFENIST, M .

DRUG DEVELOPMENT RESEARCH, 1986, 9 (03) :171-188

[5] BW234U, (CIS-9-[3-(3,5-DIMETHYL-1-PIPERAZINYL)PROPYL]CARBAZOLE DIHYDROCHLORIDE) - A NOVEL ANTIPSYCHOTIC AGENT [J].

FERRIS, RM ;

HARFENIST, M ;

MCKENZIE, GM ;

COOPER, B ;

SOROKO, FE ;

MAXWELL, RA .

JOURNAL OF PHARMACY AND PHARMACOLOGY, 1982, 34 (06) :388-390

[6] EVIDENCE THAT THE POTENTIAL ANTIPSYCHOTIC AGENT RIMCAZOLE (BW U-234) IS A SPECIFIC, COMPETITIVE ANTAGONIST OF SIGMA-SITES IN BRAIN [J].

FERRIS, RM ;

TANG, FLM ;

CHANG, KJ ;

RUSSELL, A .

LIFE SCIENCES, 1986, 38 (25) :2329-2337

[7] THE EFFECTS OF PHENCYCLIDINE AND N-ALLYLNORMETAZOCINE ON MIDBRAIN DOPAMINE NEURONAL-ACTIVITY [J].

FREEMAN, AS ;

BUNNEY, BS .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 104 (3-4) :287-293

[8] EFFECTS OF PHENCYCLIDINE ON VENTRAL TEGMENTAL A-10 DOPAMINE NEURONS IN THE RAT [J].

FRENCH, ED .

NEUROPHARMACOLOGY, 1986, 25 (03) :241-248

[9] EFFECTS OF N-ALLYLNORMETAZOCINE (SKF-10,047), PHENCYCLIDINE, AND OTHER PSYCHOMOTOR STIMULANTS IN THE RAT FOLLOWING 6-HYDROXYDOPAMINE LESION OF THE VENTRAL TEGMENTAL AREA [J].

FRENCH, ED .

NEUROPHARMACOLOGY, 1986, 25 (04) :447-450

[10] PSYCHOTROPIC ACTIONS OF BW-234U IN THE TREATMENT OF INPATIENT SCHIZOPHRENICS - A DOSE-RANGE STUDY [J].

GUY, W ;

MANOV, G ;

WILSON, WH ;

BAN, TA ;

FJETLAND, OK ;

MANBERG, PJ ;

DREN, AT .

DRUG DEVELOPMENT RESEARCH, 1983, 3 (03) :245-252

← 1 2 →