EPIDERMODYSPLASIA VERRUCIFORMIS VERSUS DISSEMINATED VERRUCAE PLANAE - IS EPIDERMODYSPLASIA VERRUCIFORMIS A GENERALIZED INFECTION WITH WART VIRUS

被引:55
作者
JABLONSKA, S
ORTH, G
JARZABEKCHORZELSKA, M
RZESA, G
OBALEK, S
GLINSKI, W
FAVRE, M
CROISSANT, O
机构
[1] INST GUSTAVE ROUSSY,F-94800 VILLEJUIF,FRANCE
[2] INST PASTEUR,F-75015 PARIS,FRANCE
关键词
D O I
10.1111/1523-1747.ep12530383
中图分类号
R75 [皮肤病学与性病学];
学科分类号
100206 ;
摘要
Recently it has been shown that epidermodysplasia verruciformis is induced by human papilloma/virus different from the papilloma/virus of warts, and that 2 distinct viruses - designated HPV-3 and HPV-4 - are responsible for it. Ten cases of epidermodysplasia verruciformis were found to have been caused by HPV-3. Clinically and histologically, as well as in the often depressed cell-mediated immunity they closely resembled long-standing verrucae planae, also caused by HPV-3. Contrariwise, in epidermodysplasia verruciformis caused by HPV-4 there are characteristic red, red-brown, and depigmented, pityriasis versicolor-like plaques, and malignant transformation seems almost inevitable. Cases due to HPV-3 may be abortive or even regressive, or stationary, and hard to distinguish from flat warts. No malignant conversion was seen in patients infected only with HPV-3, whereas it occurred in 2 patients infected with both viruses: HPV-3 and HPV-4. Pigmented plaques are the most important adverse prognostic sign in EV induced by HPV-3.
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页码:114 / 119
页数:6
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