SYNTHESIS OF LYSYL OXIDASE IN EXPERIMENTAL HEPATIC-FIBROSIS

被引：27

作者：

WAKASAKI, H

OOSHIMA, A

机构：

[1] Department of Pathology, Wakayama Medical College, Wakayama, 640

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期

关键词：

D O I：

10.1016/0006-291X(90)90993-W

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The synthesis of lysyl oxidase, which initiates the cross-linking of collagen and elastin, was investigated in carbon tetrachloride (CCl4) induced fibrotic liver of rat. Lysyl oxidase activity of the fibrotic liver was 4 times greater than that of normal liver. mRNAs from the livers of normal and CCl4-treated rats were prepared for in vitro protein synthesis and the products were analyzed by immunoprecipitation with a monoclonal antibody against lysyl oxidase. The mRNAs from the fibrotic liver gave more than 3 times higher level of messenger copies for lysyl oxidase than did mRNAs from normal liver. The molecular weight of the nascent lysyl oxidase was 48,000. © 1990.

引用

页码：1201 / 1204

页数：4

共 21 条

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[2]

NATURE AND LOCATION OF INTRAMOLECULAR CROSS-LINKS IN COLLAGEN [J].