TUBULAR FUNCTION IN ADULT POLYCYSTIC KIDNEY-DISEASE

被引：36

作者：

PREUSS, H ^{[1
]}

GEOLY, K ^{[1
]}

JOHNSON, M ^{[1
]}

CHESTER, A ^{[1
]}

KLIGER, A ^{[1
]}

SCHREINER, G ^{[1
]}

机构：

[1] GEORGETOWN UNIV,SCH MED,DEPT PATHOL,WASHINGTON,DC 20007

来源：

NEPHRON | 1979年 / 24卷 / 04期

关键词：

D O I：

10.1159/000181715

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Various tubular functions were assessed in 10 patients with polycystic kidney disease (PKD). Three relatively unique abnormalities were apparent in many of these patients - an inability to maximally concentrate urine, a decrease in ability to lower urine pH after acute acid challenge, and an inability to excrete adequate amounts of ammonium during persistent acid challenge. The defects in urinary acidification and ammonium excretion in PKD have not been previously described.

引用

页码：198 / 204

页数：7

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