INVITRO-STUDIES ON THE INFLUENCE OF CATIONS, NEUROTRANSMITTERS AND TUBOCURARINE ON CALCIUM-GANGLIOSIDE-INTERACTIONS

被引：25

作者：

MUHLEISEN, M ^{[1
]}

PROBST, W ^{[1
]}

WIEGANDT, H ^{[1
]}

RAHMANN, H ^{[1
]}

机构：

[1] UNIV MARBURG,INST PHYSIOL CHEM 1,D-3550 MARBURG,FED REP GER

来源：

LIFE SCIENCES | 1979年 / 25卷 / 09期

关键词：

D O I：

10.1016/0024-3205(79)90524-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The influence of K+, Na+, Mg++, Li+, a serotonin, acetylcholine and tubocurarine on calcium-ganglioside-interactions was studied by way of equilibrium dialysis using 45Ca as tracer. Experiments were carried out at 22 °C and 4 °C, respectively. The concentrations of the substances were in the range of physiologically relevant conditions. Cations caused a release of Ca++ from calcium-ganglioside-complexes in the sequence of their molar efficiency: Mg++ ≈ Li+ > K+ ≈ Na+. Tubocurarine, serotonin and acetylcholine also affected calcium-ganglioside-interactions. Ca++ was displaced from ganglioside most effectively by tubocurarine, followed by serotonin, whereas acetylcholine competed considerably more weakly. © 1979.

引用

页码：791 / 796

页数：6

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