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HEPATIC-FIBROSIS AND IRON ACCUMULATION DUE TO ENDOTOXIN-INDUCED HEMORRHAGE IN THE GERBIL
被引:15
作者
:
CARTHEW, P
论文数:
0
引用数:
0
h-index:
0
机构:
MRC Toxicology Unit, MRC Laboratories, Carshalton, Surrey SM5 4EF, Woodmansterne Road
CARTHEW, P
EDWARDS, RE
论文数:
0
引用数:
0
h-index:
0
机构:
MRC Toxicology Unit, MRC Laboratories, Carshalton, Surrey SM5 4EF, Woodmansterne Road
EDWARDS, RE
DORMAN, BM
论文数:
0
引用数:
0
h-index:
0
机构:
MRC Toxicology Unit, MRC Laboratories, Carshalton, Surrey SM5 4EF, Woodmansterne Road
DORMAN, BM
机构
:
[1]
MRC Toxicology Unit, MRC Laboratories, Carshalton, Surrey SM5 4EF, Woodmansterne Road
来源
:
JOURNAL OF COMPARATIVE PATHOLOGY
|
1991年
/ 104卷
/ 03期
关键词
:
D O I
:
10.1016/S0021-9975(08)80042-4
中图分类号
:
R36 [病理学];
学科分类号
:
100104 ;
摘要
:
This study reports the findings of hepatic fibrosis and the accumulation of iron in the livers of 12 gerbils. The primary lesion was a haemorrhagic necrosis of the liver that was identical to that produced experimentally in the gerbil by administration of E. coli endotoxin lipopolysaccharide. The resulting extravasation of blood caused focal histiocytic reactions. The number of lesions increased with age, eventually resulting in a micronodular cirrhosis after 9 to 12 months owing to repeated episodes of endotoxin-induced haemorrhages in the liver. The accumulation of iron occurred in perisinusoidal cells, Kupffer cells and hepatocytes. The perisinusoidal cells were responsible for the subsequent hepatic fibrosis. The fibrosis associated with this condition appears to result from iron accumulation in the liver, following haemorrhage caused by endotoxin lipopolysaccharide. The gerbil is the first recorded rodent species to develop hepatic fibrosis in response to hepatic iron overload. © 1991 Academic Press Limited.
引用
收藏
页码:303 / 311
页数:9
相关论文
共 22 条
[1]
HEPATIC-INJURY IN CHRONIC IRON OVERLOAD - ROLE OF LIPID-PEROXIDATION
BACON, BR
论文数:
0
引用数:
0
h-index:
0
机构:
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
BACON, BR
BRITTON, RS
论文数:
0
引用数:
0
h-index:
0
机构:
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
BRITTON, RS
[J].
CHEMICO-BIOLOGICAL INTERACTIONS,
1989,
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: 183
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226
[2]
BHJAGWANDEAN BS, 1987, J PATHOL, V151, P47
[3]
BOTHWELL TH, 1979, IRON METABOLISM MAN, P105
[4]
INFLUENCE OF NEOMYCIN + INGESTED ENDOTOXIN IN PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN ADULT RAT
BROITMAN, SA
论文数:
0
引用数:
0
h-index:
0
BROITMAN, SA
GOTTLIEB, LS
论文数:
0
引用数:
0
h-index:
0
GOTTLIEB, LS
ZAMCHECK, N
论文数:
0
引用数:
0
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0
ZAMCHECK, N
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
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CARTHEW P, 1991, IN PRESS HEPATOLOGY
[6]
INCREASED PRODUCTION OF COLLAGEN INVIVO BY HEPATOCYTES AND NONPARENCHYMAL CELLS IN RATS WITH CARBON TETRACHLORIDE-INDUCED HEPATIC-FIBROSIS
CHOJKIER, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
CHOJKIER, M
LYCHE, KD
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
LYCHE, KD
FILIP, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
FILIP, M
[J].
HEPATOLOGY,
1988,
8
(04)
: 808
-
814
[7]
DUBIN IN, 1955, AM J CLIN PATHOL, V25, P514
[8]
ALCOHOL INDUCED LIVER-DISEASE
FLEMING, KA
论文数:
0
引用数:
0
h-index:
0
FLEMING, KA
MCGEE, JO
论文数:
0
引用数:
0
h-index:
0
MCGEE, JO
[J].
JOURNAL OF CLINICAL PATHOLOGY,
1984,
37
(07)
: 721
-
733
[9]
HEPATIC LIPOCYTES - THE PRINCIPAL COLLAGEN-PRODUCING CELLS OF NORMAL RAT-LIVER
FRIEDMAN, SL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
FRIEDMAN, SL
ROLL, FJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
ROLL, FJ
BOYLES, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
BOYLES, J
BISSELL, DM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
BISSELL, DM
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1985,
82
(24)
: 8681
-
8685
[10]
FUJIWARA K, 1978, JPN J EXP MED, V48, P467
←
1
2
3
→
共 22 条
[1]
HEPATIC-INJURY IN CHRONIC IRON OVERLOAD - ROLE OF LIPID-PEROXIDATION
BACON, BR
论文数:
0
引用数:
0
h-index:
0
机构:
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
BACON, BR
BRITTON, RS
论文数:
0
引用数:
0
h-index:
0
机构:
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
LOUISIANA STATE UNIV, SCH MED, DEPT BIOPHYS, SHREVEPORT, LA 71130 USA
BRITTON, RS
[J].
CHEMICO-BIOLOGICAL INTERACTIONS,
1989,
70
(3-4)
: 183
-
226
[2]
BHJAGWANDEAN BS, 1987, J PATHOL, V151, P47
[3]
BOTHWELL TH, 1979, IRON METABOLISM MAN, P105
[4]
INFLUENCE OF NEOMYCIN + INGESTED ENDOTOXIN IN PATHOGENESIS OF CHOLINE DEFICIENCY CIRRHOSIS IN ADULT RAT
BROITMAN, SA
论文数:
0
引用数:
0
h-index:
0
BROITMAN, SA
GOTTLIEB, LS
论文数:
0
引用数:
0
h-index:
0
GOTTLIEB, LS
ZAMCHECK, N
论文数:
0
引用数:
0
h-index:
0
ZAMCHECK, N
[J].
JOURNAL OF EXPERIMENTAL MEDICINE,
1964,
119
(04)
: 633
-
&
[5]
CARTHEW P, 1991, IN PRESS HEPATOLOGY
[6]
INCREASED PRODUCTION OF COLLAGEN INVIVO BY HEPATOCYTES AND NONPARENCHYMAL CELLS IN RATS WITH CARBON TETRACHLORIDE-INDUCED HEPATIC-FIBROSIS
CHOJKIER, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
CHOJKIER, M
LYCHE, KD
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
LYCHE, KD
FILIP, M
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
UNIV CALIF SAN DIEGO,LA JOLLA,CA 92093
FILIP, M
[J].
HEPATOLOGY,
1988,
8
(04)
: 808
-
814
[7]
DUBIN IN, 1955, AM J CLIN PATHOL, V25, P514
[8]
ALCOHOL INDUCED LIVER-DISEASE
FLEMING, KA
论文数:
0
引用数:
0
h-index:
0
FLEMING, KA
MCGEE, JO
论文数:
0
引用数:
0
h-index:
0
MCGEE, JO
[J].
JOURNAL OF CLINICAL PATHOLOGY,
1984,
37
(07)
: 721
-
733
[9]
HEPATIC LIPOCYTES - THE PRINCIPAL COLLAGEN-PRODUCING CELLS OF NORMAL RAT-LIVER
FRIEDMAN, SL
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
FRIEDMAN, SL
ROLL, FJ
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
ROLL, FJ
BOYLES, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
BOYLES, J
BISSELL, DM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SAN FRANCISCO,DEPT PATHOL,GLADSTONE FDN LABS CARDIOVASC DIS,SAN FRANCISCO,CA 94143
BISSELL, DM
[J].
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
1985,
82
(24)
: 8681
-
8685
[10]
FUJIWARA K, 1978, JPN J EXP MED, V48, P467
←
1
2
3
→