PREPARATION AND BIOLOGICAL EVALUATION OF ETHYLCELLULOSE MICROSPHERES CONTAINING TOLMETIN

被引：7

作者：

PUGLISI, G

GIAMMONA, G

SANTAGATI, NA

CARLISI, B

VILLARI, A

SPAMPINATO, S

机构：

[1] UNIV PALERMO,DIPARTIMENTO CHIM & TECNOL FARMACEUT,I-90132 PALERMO,ITALY

[2] UNIV MESSINA,DIPARTIMENTO FARMACOCHIM,I-98010 MESSINA,ITALY

[3] UNIV BOLOGNA,IST FARMACOL,I-40126 BOLOGNA,ITALY

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1992年 / 18卷 / 09期

关键词：

D O I：

10.3109/03639049209069308

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Tolmetin microspheres were prepared by the coacervation process from the ethylcellulose. Microspheres were obtained both in presence and without protecting colloids, such as polyisobutilene (PIB) or ethyl-vinylacetate copolimers (EVA). The effect of these agents on the preparation, drug content, wall thickness, surface morphology, drug dissolution and release from microspheres, were evaluated. The dissolution rate analysis was carried out also in the presence of a surfactant (Tween 80) at different pH values. In addition, microspheres containing Tolmetin as a core material were submitted to biological tests, in comparison with the free drug, to evaluate upon experimental models the antipyretic activity and the gastric tolerability.

引用

页码：939 / 959

页数：21