THE REMARKABLY HIGH REACTIVITY OF ALPHA-CYANO-ALPHA-FLUOROPHENYLACETYL CHLORIDE (CFPA-CL) TOWARDS HINDERED NUCLEOPHILES IN ENANTIOMERIC EXCESS DETERMINATION

被引：21

作者：

TAKEUCHI, Y

ITOH, N

KOIZUMI, T

机构：

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 20期

关键词：

D O I：

10.1039/c39920001514

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The reaction of PhCF(CN)COCl 2b with 3,3-dimethylbutan-2-ol 5 was found to proceed more than 500 times faster than that of PhCCF3(OMe)COCl (MTPA-Cl) 1b, suggesting that the CFPA method should potentially lead to much less kinetic resolution than the currently much-used MTPA method in enantiometric excess determinations.

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页码：1514 / 1515

页数：2

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