CHANGES IN THE FREQUENCY OF SPLENIC IMMUNOCOMPETENT CELLS IN RATS EXPOSED TO CARBON-MONOXIDE DURING GESTATION

被引:4
作者
GIUSTINO, A
CARRATU, MR
BRIGIANI, GS
DESALVIA, MA
PELLEGRINO, NM
STEARDO, L
JIRILLO, E
CUOMO, V
机构
[1] UNIV BARI,SCH MED,INST PHARMACOL,I-70124 BARI,ITALY
[2] UNIV BARI,SCH MED,INST IMMUNOL,I-70124 BARI,ITALY
关键词
D O I
10.3109/08923979409007095
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The aim of the present study was to evaluate whether prenatal exposure to relatively low concentrations of carbon monoxide (CO) may alter the frequency of splenic cells either: in young (15 - 21 days) or in aged rats (18 months). Wistar female rats were exposed to 75 and 150 ppm of CO from day 0 to day 20 of pregnancy, respectively. The results show that prenatal exposure to 150 ppm of CO significantly decreases the number of leucocyte common antigen (LCA+) cells in 21 day old male rats, whereas other cellular populations, such as macrophages, Major Histocompatibility (MHC) II cells, T and B lymphocytes display only a trend towards a reduction without achieving statistical significance. The alterations in LCA+ cell frequency produced by gestational exposure to CO were reversible. These data further extend previous findings showing that rats prenatally exposed to moderate concentrations of CO exhibit subtle immunological changes in the absence of overt signs of toxicity.
引用
收藏
页码:281 / 292
页数:12
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