GAMMA-AMINOBUTYRIC-ACID, RECEPTOR FUNCTION IS MODULATED BY CYCLIC-GMP

被引：8

作者：

BRADSHAW, DJ

SIMMONS, MA

机构：

[1] The Neuropharmacology Laboratory, Department of Pharmacology, Marshall University School of Medicine, Huntington

来源：

BRAIN RESEARCH BULLETIN | 1995年 / 37卷 / 01期

关键词：

CYCLIC GMP; DORSAL ROOT GANGLION; GABA(A); SENSORY NEURONS;

D O I：

10.1016/0361-9230(94)00260-6

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate nervous system. Modulatory effects of intracellular ATP on the GABA response in isolated bullfrog dorsal root ganglion neurons were examined using whole-cell voltage clamp. Investigation of the plausible mechanisms ATP might utilize to regulate the GABA response led to the discovery that intracellular cyclic GMP may play an important role in modulating inhibitory neurotransmission, This modulatory effect of cyclic GMP is likely to be mediated via a cyclic GMP-dependent protein kinase.

引用

页码：67 / 72

页数：6

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