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DIAGNOSIS OF HERPES-SIMPLEX ENCEPHALITIS - APPLICATION OF POLYMERASE CHAIN-REACTION TO CEREBROSPINAL-FLUID FROM BRAIN-BIOPSIED PATIENTS AND CORRELATION WITH DISEASE

被引：426
作者：
LAKEMAN, FD
WHITLEY, RJ
ALFORD, C
COBBS, CG
MORAWETZ, R
SOONG, S
HIRSCH, MS
DOLAN, R
BETTS, R
REICHMAN, R
COREY, L
LEVIN, M
HANDLEY, D
CONNER, J
SPECTOR, S
OXMAN, M
RICHMAN, D
HAYDEN, F
GREENLEE, J
LINNEMANN, C
POWELL, D
DURAK, D
POLLARD, R
JONCAS, J
ARVIN, A
YEAGER, A
WRIGHT, P
EDWARDS, C
KLEIMAN, M
FIFE, K
LIU, K
HINTHORN, D
PAZIN, G
HO, M
BARINGER, R
COHEN, M
LEMON, S
CHOW, A
WEIL, M
TILLES, J
机构：
[1] Department of Pediatrics, Microbiology and Medicine, University of Alabama, Birmingham
[2] Department of Biostatistics, University of Alabama, Birmingham
[3] Massachusetts General Hospital, Boston
[4] University ofRochester, Rochester, NY
[5] University of Washington, Seattle
[6] University ofColorado, Boulder
[7] Johns Hopkins University, Baltimore
[8] University of California, San Diego
[9] University ofVirginia, Richmond
[10] Ohio State University, Columbus
[11] Duke University, Durham
[12] University ofTexas, Galveston
[13] St. Justine’s Hospital, Montreal
[14] Stanford University, Stanford, CA
[15] Vanderbilt University, Nashville
[16] University of Oklahoma, Norman
[17] University of Indiana, Bloomington
[18] University of Kansas, Lawrence
[19] University of Utah, Salt Lake City
[20] University of North Carolina, Chapel Hill
[21] University of British Columbia, Vancouver
[22] Harbor-UCLA Medical Center, Torrance, CA
[23] University of Califomia, Irvine
来源：
JOURNAL OF INFECTIOUS DISEASES | 1995年 / 171卷 / 04期
关键词：
D O I：
10.1093/infdis/171.4.857
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Isolation of herpes simplex virus (HSV) from brain tissue after biopsy has been considered the reference standard for the diagnosis of herpes simplex encephalitis (HSE). During the evaluation of antiviral treatment of HSE, cerebrospinal fluid (CSF) was obtained from patients with clinical disease indicative of HSE who underwent diagnostic brain biopsy. HSV DNA was detected by polymerase chain reaction (PCR) in CSF of 53 (98%) of 54 patients with biopsy-proven HSE and was detected in all 18 CSF specimens obtained before brain biopsy from patients with proven HSE. Four of 19 CSF specimens were positive after 2 weeks of antiviral therapy. Positive results were found in 3 (6%) of 47 patients whose brain tissue was culture-negative. Detection of HSV DNA in the CSF correlated significantly with age and focal radiographic findings. Thus, PCR detection of HSV DNA should be the standard for diagnosis of HSE.
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页码：857 / 863
页数：7
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