ACUTE DISTRIBUTION OF VARIOUS C-14 COMPOUNDS IN MICE AS DETERMINED BY WHOLE-BODY AUTORADIOGRAPHY - ADJUNCT FOR RADIOPHARMACEUTICAL SYNTHESIS

被引：4

作者：

COHEN, MB ^{[1
]}

MASUOKA, DT ^{[1
]}

ALCARAZ, AF ^{[1
]}

SPOLTER, L ^{[1
]}

机构：

[1] VET ADM HOSP,SEPULVEDA,CA 91343

来源：

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES | 1977年 / 28卷 / 05期

关键词：

ACCELERATORS; CYCLOTRON - BIOMEDICAL ENGINEERING - Living Systems Studies - DENSITOMETERS - RADIOACTIVE MATERIALS - RADIOGRAPHY;

D O I：

10.1016/0020-708X(77)90183-1

中图分类号：

TL [原子能技术]; O571 [原子核物理学];

学科分类号：

0827 ; 082701 ;

摘要：

The acute distribution of C-14 labeled asparagine, arginine, glycine, citric acid, fructose and glucosamine is evaluated in mice by whole-body autoradiography using a new digital microdensitometer. The results are utilized to help select compounds of interest for labeling with ultra-short-lived positron emitters, such as C-11 and N-13. Quantitative whole-body autoradiography in mice appears to be an excellent method for screening and selecting compounds of interest for radiopharmaceutical synthesis, but species differences do exist.

引用

页码：491 / 496

页数：6

共 11 条

[1] EFFECTS OF ALKALOSIS ON RENAL CITRATE METABOLISM IN DOGS INFUSED WITH CITRATE [J].

BALAGURABARUCH, S ;

BURICH, RL ;

KING, VF .

AMERICAN JOURNAL OF PHYSIOLOGY, 1973, 225 (02) :385-388

[2]

BLAHD WH, 1958, PRACTICE NUCLEAR MED, P93

[3]

COHEN MB, 1973, P IAEA WHO S COPENHA, V1, P483

[4]

COHEN MB, 1974, J NUCL MED, V15, P119

[5]

DUDA GD, 1958, J BIOL CHEM, V232, P303

[6]

GELBARD AS, 1974, J NUCL MED, V15, P1223

[7] ACUTE DISTRIBUTION OF C-14-AMINO ACIDS IN MICE AS DETERMINED BY WHOLE-BODY AUTORADIOGRAPHY - ADJUNCT FOR RADIOPHARMACEUTICAL SYNTHESIS [J].

MASUOKA, DT ;

ALCARAZ, AF ;

COHEN, MB ;

SPOLTER, L .

INTERNATIONAL JOURNAL OF APPLIED RADIATION AND ISOTOPES, 1973, 24 (12) :705-&

[8]

PFEIFFER E, TO BE PUBLISHED

[9]

SPOLTER L, 1976, J NUCL MED, V17, P558

[10]

ULLBERG S, 1954, ACTA RADIOL S118

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