URINARY EXCRETION OF DRUG AND ITS MAIN METABOLITE IN MAN, AFTER ADMINISTRATION OF (+/-)-, (+)- AND (-)-ETHYLAMPHETAMINE

被引：26

作者：

BECKETT, AH

BROOKES, LG

SHENOY, EVB

机构：

[1] Pharmacy Department, Chelsea College, University of London, London, SW.3, Manresa Road

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / S 21卷

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08366.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The urinary excretion of ethylamphetamine and its metabolite amphetamine was studied in man after oral administration of (±)‐, (+)‐, and (‐)‐ethylamphetamine hydrochloride. The rates of excretion of these amines are dependant on the pH of the urine. At acid values, the (+)‐isomer is metabolized faster and to a greater extent than the (‐)‐isomer, which is excreted mostly unchanged. The effect of alkyl chain length on stereoselective metabolism of N‐alkylamphetamines is discussed. 1969 Royal Pharmaceutical Society of Great Britain

引用

页码：S151 / &

共 8 条

[1] EXCRETION OF DEXAMPHETAMINE AND ITS DERIVATIVES [J].