MECHANISMS OF INTERPHASE TRANSPORT .2. THEORETICAL CONSIDERATIONS AND EXPERIMENTAL EVALUATION OF INTERFACIALLY CONTROLLED TRANSPORT IN SOLUBILIZED SYSTEMS

被引：21

作者：

GOLDBERG, AH

HIGUCHI, WI

机构：

[1] College of Pharmacy, Unicersity of Michigan, Ann Arbor, Michigan

[2] Department of Pharmaceutics, College of Pharmaceutical Sciences, Columbia University, New York, New York, 10023

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 11期

关键词：

Diffusion; effects—drug transport rates; Interfacial barrier; effect—transport process; Interphase transport; mechanisms—solubilized systems; Oil phase; micron‐sized spheres—infinite diffusion layer; production;

D O I：

10.1002/jps.2600581109

中图分类号：

R914 [药物化学];

学科分类号：

100705 [微生物与生化药学];

摘要：

Equations were derived to describe the transport rate of a solute from an aqueous environment to an oil phase present as finely dispersed droplets. The basic diffusion equations included the effects of micellar solubilization in the aqueous phase and an interfacial barrier at the o/w interface. Two separate experimental systems were evaluated by fitting data to the rates predicted theo‐retically. System I was composed of polysorbate 80 as the surfactant, isopropyl myristate as the oil phase, and 2,3‐bis‐(p‐methoxyphenyl)‐indole as the drug solute. The second system was composed of mineral oil as the “sink”, dibutyl phthalate as the solute, and polysorbate 80. The aqueous phase of System II contained 75% sucrose to increase the viscosity. The experimental transport rates of the solutes most closely fit the rates predicted by the theory which assumes that an interfacial barrier was rate determining. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：1341 / &

共 5 条

[1]

SOLUBILIZING PROPERTIES OF BILE SALT SOLUTIONS .1. EFFECT OF TEMPERATURE AND BILE SALT CONCENTRATION ON SOLUBILIZATION OF GLUTETHIMIDE GRISEOFULVIN AND HEXESTROL [J].